2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140968
    Mal-PEG2-alcohol 34321-81-8 99.67%
    Mal-PEG2-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG2-alcohol
  • HY-140540
    N-Boc-N-bis(PEG4-acid) 2093152-88-4
    N-Boc-N-bis(PEG4-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-Boc-N-bis(PEG4-acid)
  • HY-W067061
    Hydroxy-PEG2-(CH2)2-Boc 133803-81-3 98.25%
    Hydroxy-PEG2-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG2-(CH2)2-Boc is extracted from patent WO2004008101A2 (compound 196). Hydroxy-PEG2-(CH2)2-Boc is also a PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG2-(CH2)2-Boc
  • HY-132064
    FmocNH-PEG4-t-butyl ester 2148295-94-5
    FmocNH-PEG4-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    FmocNH-PEG4-t-butyl ester
  • HY-126888
    Mal-PEG5-NHS ester 1807537-42-3 99.04%
    Mal-PEG5-NHS ester is an Alkyl/ether and PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Mal-PEG5-NHS ester
  • HY-141377
    m-PEG9-Br 125562-30-3 ≥98.0%
    m-PEG9-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG9-Br
  • HY-140261
    NH-bis(PEG4-C2-NH-Boc) 2182601-75-6
    NH-bis(PEG4-C2-NH-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH-bis(PEG4-C2-NH-Boc)
  • HY-115384
    Amino-PEG5-C2-acid 1191078-74-6
    Amino-PEG5-C2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Amino-PEG5-C2-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Amino-PEG5-C2-acid
  • HY-141330
    m-PEG8-thiol 651042-83-0 99.94%
    m-PEG8-thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG8-thiol
  • HY-140301
    DBCO-PEG4-Desthiobiotin 2032788-37-5
    DBCO-PEG4-Desthiobiotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG4-Desthiobiotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG4-Desthiobiotin
  • HY-W039197
    Acid-PEG4-mono-methyl ester 2028284-75-3
    Acid-PEG4-mono-methyl ester is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.
    Acid-PEG4-mono-methyl ester
  • HY-141273
    Methyltetrazine-PEG8-PFP ester 2353409-49-9 98.06%
    Methyltetrazine-PEG8-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methyltetrazine-PEG8-PFP ester
  • HY-140039
    Bis-propargyl-PEG11 1351373-49-3 99.79%
    Bis-propargyl-PEG11 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bis-propargyl-PEG11 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Bis-propargyl-PEG11
  • HY-117042
    Biotin-PEG2-C6-azide 1011268-29-3
    Biotin-PEG2-C6-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTAC. Biotin-PEG2-C6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Biotin-PEG2-C6-azide
  • HY-130824
    Bis-PEG10-NHS ester 2221949-02-4
    Bis-PEG10-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG10-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Bis-PEG10-NHS ester
  • HY-130523
    Tos-PEG5-Boc 581065-94-3
    Tos-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tos-PEG5-Boc
  • HY-140916
    Dde Biotin-PEG4-azide 1802907-93-2 99.44%
    Dde Biotin-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Dde Biotin-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Dde Biotin-PEG4-azide
  • HY-145090
    DBCO-N-bis(PEG4-NHS ester) 2639395-38-1
    DBCO-N-bis(PEG4-NHS ester) is a PEG linker which contains two PEG4-NHS ester and a DBCO group. DBCO-N-bis(PEG4-NHS ester) is useful for protein modification or labeling. DBCO-N-bis(PEG4-NHS ester) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-N-bis(PEG4-NHS ester)
  • HY-107608S
    Leukotriene B4-d4 124629-74-9 99.1%
    Leukotriene B4-d4 is the deuterium labeled Leukotriene B4. Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Leukotriene B4-d<sub>4</sub>
  • HY-134711A
    Amine-PEG6-thiol hydrochloride
    Amine-PEG6-thiol hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amine-PEG6-thiol hydrochloride
PROTAC Linkers Isoform Comparison

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